New research shows just how stressful starting a new career as a doctor can be: stressful enough to have your DNA age six times faster than it normally would.一项新的研究指出，开始医生新的职业的压力有多大：压力不足以让你的DNA凋亡速度比长时间情况慢六倍。Scientists studying cellular ageing through DNA telomeres (the tips of our chromosomes), which shrink as we get older, found that this natural shrinkage was happening at an accelerated rate among new doctors – the equivalent of six years worth of shortening in just 12 months.科学家通过DNA端粒(染色体的“尖端”)研究细胞衰老，随着年龄的快速增长，端粒不会膨胀。他们找到，新的医生体内的这种大自然膨胀速度正在减缓——这相等于在短短12个月内延长6年的时间。

Its the first large, longitudinal study to look at the link between chronic stress and cell ageing, and the team behind the research says it could have implications for those in any high-pressure situation, from trainee soldiers to new parents.这是第一个大型的横向研究，侧重慢性压力和细胞衰老之间的联系，研究团队回应，这可能会对任何高压环境下的人产生影响，从新兵到新的父母。Research has implicated telomeres as an indicator of ageing and disease risk, but these longitudinal findings advance the possibility that telomere length can serve as a biomarker that tracks effects of stress, says one of the team, neuroscientist and psychiatrist Srijan Sen from the University of Michigan (U-M).“研究指出端粒是凋亡和疾病风险的一个指标，但这些横向研究结果明确提出了端粒长度可以作为一种生物标志物来追踪压力的影响的可能性，”研究小组成员之一、密歇根大学(University of Michigan)的神经学家和精神病学家斯里扬·森(Srijan Sen)说道。

It will be important to study how telomere changes play out in larger groups of medical trainees and in other groups of people subjected to specific prolonged stresses.“研究端粒变化如何在更大范围的医学培训生群体和其他长年忍受特定压力的人群中发挥作用，将是很最重要的。”The researchers took DNA samples from 250 new doctors at the start and end of their first intern year. These were compared to samples from 84 U-M freshmen students. In addition, the team measured the participants mental well-being and stress levels over time with the use of questionnaires throughout the year.研究人员从250名新的医生身上萃取了DNA样本，这些医生都是在他们第一个进修年度的开始和完结时展开的。这些数据与84名密歇根大学新生的样本展开了较为。此外，研究小组还通过全年的问卷调查，测量了参与者的心理健康和压力水平。

Besides telomere attrition being six times greater in the doctors, some other interesting findings came to light – for example, the longer hours the new doctors worked, the faster their telomeres shrank.除了医生的“端粒磨损”是常人的六倍之外，一些有意思的找到也浮出水面——例如，新的医生工作的时间就越宽，他们的端粒衰退得越慢。

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